| Modulname |
UNIC: University of Lodz: Achievements and perspectives of stem cell therapy/regenerative medicine |
| Gebiet |
|
| Profil |
Profil International
Profil Freie Studien
Profil Zukunft
|
| CPs |
5 CP |
| Campus |
Hier geht
es zum Vorlesungsverzeichnis |
| Voraussetzungen |
The module is held in English, so sufficient language skills are required. |
| Besonderheiten |
TN-Plätze: 10/30
Termin der ersten Sitzung: Not determined yet.
Anmeldung:
In order to register please send your request to unic@uni.lodz.pl
Deadline: 30.09.2022
After successful registration, please send an email with registration confirmation to ecampus-optionalbereich@rub.de. This is necessary so that registration in Campus can take place after successful completion of the module.
Prüfungstermin: Not determined yet.
Zusammensetzung der Endnote: The presence in both lecture and seminar is necessary condition to take multi-choice test exam at the end of the lecture; activity and term paper at the end of the course are required in seminar. The final grade is an arithmetic mean of exam grade and term paper plus activity. |
| Blockseminar |
Nein |
| Vorkenntnisse |
The module is held in English, so sufficient language skills are required. |
| Veranstaltungszeit |
siehe Campus |
| Dozenten |
siehe Campus |
| Arbeitsaufwand |
Lecture: personal work time 40 h, attendance time 20 h; workload 2:1
Seminar: personal work time 60 h, attendance time 30 h; workload 2:1 |
| Literatur |
Introductory references
J Slack “Stem Cells. A Very Short Introduction” Oxford University Press, New York, 2012
C Mummery, A van de Slope, B Roelen, H Clevers “Stem Cells. Scientific Facts and Fiction. Academic Press 2014. |
| Modulteil |
siehe Campus |
| Modultyp |
Profil Freie Studien, Profil International, Profil Zukunft |
| Modulanbieter |
University of Lodz |
| Inhalt |
Teil 1: Achievements and perspectives of stem cell therapy/regenerative medicine (Lecture), Exact class times still to be determined
Teil 2: Achievements and perspectives of stem cell therapy/regenerative medicine (Seminar), Exact class times still to be determined
The aim of the "Stem cells" course is to provide students with basic terms used in stem cells science and present milestones in the development of stem cell technology and its application in medicine and veterinary sciences. Real achievements of stem cells-based therapy will be shown along with critics of some unproven and unreliable reports. Therefore, a warning will be sent towards unproven applications of stem cells claimed as beneficial. Some social, philosophical, and bioethical issues will be presented.
Inhaltliche Beschreibung Teil 1:
The lectures will start from a short history of stem cell research with an emphasis on its milestones in the current and perspective therapeutic applications of stem cells. The basic characteristics of stem cells and their classification will be provided with detailed explanation of the role of pluripotent stem cells in biology and medicine. In this context reprogramming will be introduced and explained along with the specific localization of stem cells in tissues and organs (the stem cell niche). Strategies for isolation and identification of stem cells will be provided with an emphasis of surface markers-based technologies. In vivo assays to verify the true virtue of stem cells will be presented. Then significance and problems associated with embryonic stem cells and therapeutic cloning along with a short story of nuclear transfer and Dolly the clone will be presented. Reprogramming of one kind of cell into another will be explained with an important role of epigenetic modifications in this process. The revolution made in biology and philosophy by the Nobel Prize awarded induced pluripotent stem cells will be presented with a detailed history of its creation. The role of stem cells in aging and cancer will introduce into application of stem cells in medicine. The role of metabolic activity as a key determinant of stem cell aging will be described. The cancer stem cells theory and its development in the context of anticancer therapy will be presented. The problems of stem cell and its therapeutic use/perspective perception by societies will be shown. problems associated with the commercialization of stem cell products and technologies in the context of social and economical considerations will be presented.
Inhaltliche Beschreibung Teil 2: Diese sollte möglichst ausführlich und auch für fachfremde Studierende verständlich formuliert sein (von kurzen Auflistungen sollte abgesehen werden).
In the seminar, outstanding questions on stem cells will be addressed and their answers will be discussed. Some are provided below, but the discussion is not limited to them as novel topics may arouse and students may be especially interested in some other issues. What is the actual reason that stem cells may have a transient existence during development or exist throughout life in tissues? Is asymmetric cell division the heart of the stem cell existence? Embryonic stem cells versus adult stem cells. How does stem cell biology offer possibilities for regenerative medicine either through provision of cells for transplantation or by enhancement of endogenous stem cell capability? How is knowledge of stem cell biology being translated into medical practice and many aspects of horticulture and agriculture. Why in vivo assays are the true verification of the stem cells identity and in vitro assays are inherently flawed? How replicative quiescence can be explored to identify stem cells? Why do all levels in society seem to have had something to say, from presidents and religious leaders to politicians and the man on the street on the embryonic stem cells? What are specific aspects and general context of Dolly the clone? What are the true facts on Hwang Woo-suk’s Claims of SCNT-ES cell generation? Did cloning by nuclear transfer raise the possibility of being able to generate personalized ES cells? Wkat is the role of epigenetics in stem cell fate? What are challenges in induced pluripotent cell sciences? What are ethical aspects of Induced pluripotent stem cells? Considering the role of stem cells in aging the problems of rejuvenation and immortality will be discussed also in the context of epigenetics and diet. What are implications of stem cell origin of cancer. How do reports in the media influence the public perception of stem cells? Discussion about international human embryonic stem cell laws – stem cell migrants. Myths and legends about stem cells and their therapeutic applications. What is an influence of patentability of stem cell related products on their commercialization. Are health economic considerations a major determinant of ultimate uptake of stem cell products and technologies? |
| Lernziele |
A student
‒ appreciates the importance of research on stem cells in the light of leislature and social demands
‒ distinguishes totipotent, pluripotent, multipotent and monopotent stem cells
– describes reprogramming of somatic cells to a pluripotency stage
‒ explains the perspective of clinical use of stem cells
‒ describes embryonic and cancer stem cells
– discusses social and ethic aspects of the use of human stem cells
‒ finds current information on stem cells on the Internet
– extends his/her knowledge actively and independently |
